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splenic marginal zone lymphoma : ウィキペディア英語版 | splenic marginal zone lymphoma
Splenic marginal zone lymphoma (SMZL) is a lymphoma made up of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed blasts, and they invade the mantle zone of splenic follicles and erode the marginal zone, ultimately invading the red pulp of the spleen. Frequently, the bone marrow and splenic hilar lymph nodes are involved along with the peripheral blood. The neoplastic cells circulating in the peripheral blood are termed villous lymphocytes due to their characteristic appearance. ==Synonyms== Under older classification systems, the following names were used:〔
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